CAPSULATION OF TOPANAMBUR NANOPARTICLES - “HELIANTHUS TUBEROSUS” WITH SODIUM CARBOLIMETHYL CELLULOSE POLYSACCHARIDE AND THEIR RESEARCH - Студенческий научный форум

XI Международная студенческая научная конференция Студенческий научный форум - 2019

CAPSULATION OF TOPANAMBUR NANOPARTICLES - “HELIANTHUS TUBEROSUS” WITH SODIUM CARBOLIMETHYL CELLULOSE POLYSACCHARIDE AND THEIR RESEARCH

Мaksetbaeva D.R., Inagamov S.Ya. 1
1Ташкентский фармацевтический институт
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In the development of modern nanotechnology, a significant role is played by the studies of nanoparticles obtained from extracts of medicinal plants with the help of solutions of metal salts. This is due to the wide range of possibilities for their practical application, which use the specific properties of both the nanoparticles obtained from medicinal plant extracts and the materials modified by them. This work is devoted to obtaining nanoparticles and studying the physicochemical properties and stability of encapsulated nanoparticles obtained from a medicinal plant - Helianthus Tuberosus .

For the preparation of nanoparticles from Helianthus Tuberosus, an alcoholic extract of an earth pear was prepared. Fresh pears, after cleaning, were crushed to size d = 2-3 mm and dried at room temperature. The dried product of Jerusalem artichoke was crushed to form a powder. An extract was prepared from the obtained powder by means of 70% ethyl alcohol in the ratio of Jerusalem artichoke: 70% ethyl alcohol = 1:10. Vials were shaken periodically with a SHR-2D laboratory shaker. From the extracts, nanoparticles were obtained by precipitation with the help of MgSO4 salts, NaCl, Ag NO3, etc.

In the obtained extracts of Jerusalem artichoke - Helianthus Tuberosus over time, aggregation occurs. To enhance aggregative stability, natural sodium polysaccharide sodium carboxymethyl cellulose (Na-CMC) can be used. The introduction of Na-CMC largely prevents aggregation and reduces the average size of the nanoparticles. By mixing a solution of nanoparticles of Jerusalem artichoke extract with solutions of Na-CMC in various volume ratios, a nanocomposite was obtained in which nanoparticles are stabilized by the polysaccharide Na-CMC

Thus, nanoparticles were synthesized from the extract of a medicinal plant of Jerusalem artichoke - Helianthus Tuberosus with the introduction of magnesium sulfate salts. By varying the sodium polysaccharide carboxymethylcellulose concentration, aggregatively stable nanocomposites were obtained.

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