Three of the most lethal mushrooms belong to the genus Amanita: the death cap (A. phalloides) and destroying angels (A. virosa, and A. bisporigera); the fool's mushroom (A. verna) and two are from the genus Cortinarius: the deadly webcap (C. rubellus), and the fool's webcap (C. orellanus). Several species of Galerina, Lepiota, and Conocybe also contain lethal amounts of amatoxins. The following species may cause great discomfort, sometimes requiring hospitalization, but are not considered deadly:
Amanita muscaria (fly agaric) – known for its use as an entheogen, and it is now known that the toxins convert to psychoactives upon drying;
Chlorophyllum molybdites (greengills) – causes intense gastrointestinal upset;
Entoloma (pinkgills) – some species are highly poisonous, such as livid entoloma (Entoloma sinuatum), Entoloma rhodopolium, and Entoloma nidorosum. Symptoms of intense gastrointestinal upset appear after 20 minutes to 4 hours, caused by an unidentified gastrointestinal irritant;
Many Inocybe species such as Inocybe fastigiata and Inocybe geophylla contain muscarine, while Inocybe erubescens is the only one known to have caused death;
Lactarius vinaceorufescens, Lactarius uvidus – reportedly poisonous. Arora[10] reports that all yellow- or purple-staining Lactarius are "best avoided."
To prevent mushroom poisoning, mushroom gatherers need to be very familiar with the mushrooms they intend to collect as well as with any similar-looking toxic species. In addition, edibility of mushrooms may depend on methods of preparation for cooking. Collectors also need to be well aware that edibility or toxicity of some species varies with geographic location.